asd [2019-08-01 11:21:11]

aspartate-semialdehyde dehydrogenase

Locus: BSU_16750

Isoelectric point: 4.97

Molecular weight: 37.69 kDa

Protein length: 346 aa

Gene length: 1041 bp

Function: biosynthesis of threonine, lysine, dipicolic acid, peptidoglycan

Product: aspartate-semialdehyde dehydrogenase

Essential: yes

E.C.: 1.2.1.11

Synonyms

Genomic Context

Loading

Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of peptidoglycan
• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of lysine/ threonine
• Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of peptidoglycan
• Lifestyles → Sporulation → Sporulation proteins → Sporulation proteins/ other
• Groups of genes → Essential genes
• Groups of genes → Phosphoproteins → Phosphorylation on a Ser residue
• Groups of genes → Phosphoproteins → Phosphorylation on a Tyr residue

Gene

Coordinates: 1,745,991 1,747,031

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• L-aspartate 4-semialdehyde + phosphate + NADP⁺ = L-4-aspartyl phosphate + NADPH (according to Swiss-Prot)

Protein family

• aspartate-semialdehyde dehydrogenase family (single member, according to UniProt)

Modification

• phosphorylation on Ser-98 AND Tyr-146 PubMed

Structure

• 2GYY (from Streptococcus pneumoniae, 52% identity, 65% similarity) PubMed

Expression and Regulation

Operons

• Genes: asd-dapG-dapA
  Description: PubMed

  Sigma factors

  • SigK: sigma factor, PubMed, in SigK regulon
  • SigA: sigma factor, PubMed, in SigA regulon

• Genes: spoVFA-spoVFB-asd-dapG-dapA
  Description: PubMed

  Sigma factors

  • SigK: sigma factor, PubMed, in SigK regulon

  Regulation

  • expressed late during sporulation in the mother cell (SigK) PubMed

References

Loading